sistemas 2.0

The edge that binds two nodes in a network might NOT represent?. A random event. A physical interaction between two proteins. Two correlated events. The relationship transcription factor-gene target.

If you see that the edges in a network look like arrows?. You are in front of an indirect network. You can follow the information flow. The edges summarise physical interactions, i.e. protein-protein interactions. These edges cannot have a weight.

This is NOT a characteristic of an actual network?. Sparsity. Randomicity. Small world. Scale-free distribution.

Barabasi's big contribution to the network field was?. The identification of community formation of networks. The identification of power-law distribution of node connectivity. The identification of small world property. The identification of networks sparsity.

Community detection is NOT important to....?. Find new roles for unknown proteins. Identify minor hubs. Address functional annotation of nodes. Calculate node connectivity.

The interactions in the Arabidopsis Protein-Protein Interaction Network are based on: Co-expression data. Yeast-one-hybrid. Yeast-two-hybrid. Literature-curated information.

Plant-pathogen Interaction Networks revealed that evolutionarily distant pathogens: Use virulence effectors that target distinct fractions of Arabidopsis proteins. Use virulence effectors to target Arabidopsis proteins with low rates of mutation. Use virulence effectors that target a discrete fraction of common proteins that are hubs in the Arabidopsis network. Use virulence effectors that target preferentially non-hub proteins in the Arabidopsis network.

Initially, an important fraction of Arabidopsis proteins considered as "immune interactors": Was bona-fide immune proteins. Was not previously related to immune proteins. Could not be proved to play a role in immune defence. Is evolutionary conserved in terms of sequence.

Arabidopsis proteins targeted by 3 distant pathogens: Had pleiotropic phenotypes. Most of them contribute to either reinforce or weaken the immune response to pathogens to at least one pathogen. Display enhanced susceptibility phenotypes to all three pathogens in loss-of-function mutant lines. Were unrelated to immunity roles.

An important contribution of applying Systems Biology strategies to study plant immunity was NOT: Highlighting the relevance of hubs to preserve the integrity of a system. Providing capacity to uncover unknown biological roles for a given cohort of proteins. Describe defence as a series of isolated events. Relate evolutionary and functional features in Biology.